TUBERCULIN B

TARGET SPECIES: Cattle, pigs, sheep, goats, carnivores, horses.

Amoxicilina 250ml

INDICATIONS: It is used for the in vivo allergic diagnosis of bovine tuberculosis, through the single intradermal test (single test) and through the simultaneous comparative intradermal tuberculin test, together with tuberculin A.

COMPOSITION:
A dose of 0.1 ml of product contains:
Active substance:
Purified protein derivative (PPD) of Mycobacterium bovis, symbol AN5 2,000 IU.
Excipients:
Phenol: <0.05 g%
 
CONTRAINDICATIONS
Do not use on sick or convalescent animals.
Do not use within 42 days of another tuberculin or para-tuberculin allergic exam.
Do no inoculate in areas of skin lesions.

ADVERSE REACTIONS
None.
If you notice any serious reactions or other effects not stated in this leaflet, please inform your veterinarian.

ADMINISTRATION METHOD
Administer Tuberculin B by intradermal injection in a dose of 0.1 ml. Stir the bottle before use.
Single intradermal test for cattle
It is performed in animals over the age of 6 weeks. The injection site should be cleansed and clipped. Within each trimmed area, take a fold of skin between the forefinger and the thumb, and measure it with calipers, recording the value.
Administer a dose of 0.1 ml of bovine tuberculin intradermally, in the middle third of the neck.
Proper administration is confirmed by the appearance of pea-like swelling at the site of inoculation.
After 72 hours, re-measure the thickness of the skin fold at the site of inoculation, recording the value.
Interpretation of results:
a) Positive: if there is an increase of 4 mm or more in the skin fold thickness at the injection site or there are clinical signs such as: diffuse or extensive edema, exudation, necrosis, pain or inflammation of the regional lymphatic vessels or lymph nodes.
b) Inconclusive: if the clinical signs referred to above are not observed and if the increase in the skin fold thickness is more than 2 mm and less than 4 mm.

c) Negative: the increase by no more than 2 mm in the skin fold thickness, without any clinical signs.
Animals inconclusive to the single intradermal test must undergo another test after at least 42 days.
Animals that are not negative on this second test are considered to be positive.
Animals that are positive in the single intradermal test may be subjected to a comparative intradermal test if false positive reactions or interference reactions are suspected.
Simultaneous comparative test in cattle
This test is performed in animals over the age of 6 weeks by simultaneous intradermal inoculation, in separate locations, of bovine tuberculin and avian tuberculin.
On the same side of the neck, at the border between the anterior and middle third, trim and clean two inoculation sites, one located 10 cm from the crest of the neck, and another one located 12.5 cm lower, on a line parallel to the line of the shoulder. Then, measure the thickness of the fold of skin in both inoculation sites and write it down. Then, proceed with inoculating avian tuberculin in a dose of 0.1 ml, strictly intradermally, in the upper quadrate, and bovine tuberculin in the lower quadrate, in a dose of 0.1 ml, according to the single test technique. Carry out the inoculation with separate syringes and needles for each type of tuberculin.
In juveniles, the two tuberculins can be inoculated on either side of the neck in identical places, prepared the same as for the single test.
Reaction reading: after 72 hours, measure the thickness of the skin fold in the two inoculated places and write down the values obtained.
Interpret the results based on the same criteria as for the single test:
Positive reaction: if, at the site of bovine tuberculin inoculation, there is an increase of 4 mm or more in the skin fold thickness or there are clinical signs, such as: diffuse or extensive edema, exudation, necrosis, pain or inflammation of regional lymphatic vessels or lymph nodes.
Inconclusive reaction: positive or inconclusive reaction to bovine tuberculin, with the absence of any clinical signs, or when the skin fold thickness in bovine tuberculin is greater by 1-4 mm than for the reaction to avian tuberculin.
Negative reaction: no changes to bovine tuberculin, or positive or inconclusive reactions to bovine tuberculin, equal to or lower than the positive or inconclusive reactions to avian tuberculin. Clinical signs are absent in both cases. Retest any animals with inconclusive reactions to this test after 42 days using the same procedure. If these animals do not react negatively to the second test, they are considered positive.

! Before administration, carefully read the package leaflet.

RECOMMENDATIONS FOR PROPER ADMINISTRATION
Do not use Tuberculin B if you notice any visible signs of deterioration of the primary packaging.

WITHDRAWAL PERIOD
Pigs: meat and offal = zero days
Cattle, sheep, goats, horses: meat and offal = zero days; milk = zero days
 
 

STORAGE
Keep out of the reach and sight of children. Do not use after the expiration date stated on the label. Store and transport refrigerated (2-8°C). Keep away from direct sunlight. Do not freeze.

 
Bottles x10ml containing 10 ml of product (the equivalent of 100 doses of 0.1 ml).
Bottles x3ml containing 1 and 2 ml of product (the equivalent of 10, 20 doses of 0.1 ml).
Bottles x6ml containing 5 ml of product (the equivalent of 50 doses of 0.1 ml).
Not all pack sizes may be marketed.
 
 

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