TARGET SPECIES: Birds, cattle, pigs.
INDICATIONS: It is used for the in vivo allergic diagnosis of avian tuberculosis, through the single intradermal test (single test) and through the simultaneous comparative intradermal tuberculin test, together with tuberculin B.
A dose of 0.1 ml of product contains:
Active substance:
Purified protein derivative (PPD) of Mycobacterium avium, symbol D4ER 2,000 IU.
Excipients:
Phenol: <0.05 g%
Do not use on sick or convalescent animals.
Do not use within 42 days of another tuberculin or para-tuberculin allergic exam.
Do no inoculate in areas of skin lesions.
ADVERSE REACTIONS
None.
If you notice any serious reactions or other effects not stated in this leaflet, please inform your veterinarian.
ADMINISTRATION METHOD
Administer Tuberculin A by intradermal injection in a dose of 0.1 ml. Stir the bottle before use.
Single test for birds
Inoculate, strictly intradermally, a dose of 0.1 ml of product into one of the bibs.
Reactions are read 48 hours after inoculation based on clinical signs at the site of inoculation:
Positive reaction: there are pronounced swelling and edema at the site of inoculation; intense positive reactions reveal bleeding and necrosis.
Inconclusive reaction: at the site of inoculation, there is slight swelling, without an edematous character.
Negative reaction: no changes are observed at the site of inoculation.
Simultaneous test in pigs
Inoculate, strictly intradermally and simultaneously, a dose of 0.1 ml of avian tuberculin at the base of one ear and 0.1 ml of bovine tuberculin in the other ear.
Reactions are read 48 hours after inoculation based on clinical signs at the site of inoculation, for each tuberculin:
Positive reaction: at the site of inoculation, an edema has formed, accompanied by erythema and, possibly, necrosis.
Inconclusive reaction: at the site of inoculation, a nodule or hard edema up to the size of a pea forms.
Negative reaction: there are no changes at the site of inoculation.
The interpretation of the simultaneous test shall take into account the intensity of the reactions to the two tuberculins. The animals are deemed to be infected with one of the types of tuberculosis bacilli, when the reactions caused by bovine tuberculin products are greater than those caused by avian tuberculin products and vice versa.
Simultaneous comparative test in cattle
This test is performed in animals over the age of 6 weeks by simultaneous intradermal inoculation, in separate locations, of avian tuberculin, and bovine tuberculin.
On the same side of the neck, at the border between the anterior and middle third, trim and clean two inoculation sites, one located 10 cm from the crest of the neck, and another one located 12.5 cm lower, on a line parallel to the line of the shoulder. Then, measure the thickness of the fold of skin in both inoculation sites and write it down.
Then proceed with inoculating avian tuberculin in a dose of 0.1 ml, strictly intradermally, in the upper quadrate, and bovine tuberculin in the lower quadrate, in a dose of 0.1 ml. Carry out the inoculation with separate syringes and needles for each type of tuberculin.
In juveniles, the two tuberculins can be inoculated on either side of the neck in identical places.
Reaction reading: after 72 hours, measure the thickness of the skin fold in the two inoculated places and write down the values obtained.
Interpret the results based on the same criteria as for the single test:
Positive reaction: if, at the site of bovine tuberculin inoculation, there is an increase of 4 mm or more in the skin fold thickness in response to avian tuberculin, or there are clinical signs, such as: diffuse or extensive edema, exudation, necrosis, pain or inflammation of regional lymphatic vessels or lymph nodes.
Inconclusive reaction: positive or inconclusive reaction to bovine tuberculin, with the absence of any clinical signs, or when the skin fold thickness in bovine tuberculin is greater by 1-4 mm than for the reaction to avian tuberculin.
Negative reaction: no changes to bovine tuberculin, or positive or inconclusive reactions to bovine tuberculin, equal to or lower than the positive or inconclusive reactions to avian tuberculin. Clinical signs are absent in both cases.
Retest any animals with inconclusive reactions to this test after 42 days using the same procedure. If these animals do not react negatively to the second test, they are considered positive.
! Before administration, carefully read the package leaflet.
RECOMMENDATIONS FOR PROPER ADMINISTRATION
Do not use Tuberculin A if you notice any visible signs of deterioration of the primary packaging.
WITHDRAWAL PERIOD
Meat and offal: birds, pigs, cattle = zero days.
Egg = zero days.
STORAGE
Keep out of the reach and sight of children. Do not use after the expiration date stated on the label. Store and transport refrigerated (2-8°C). Keep away from direct sunlight. Do not freeze.
Not all pack sizes may be marketed.
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